Somatosensory responses in a human motor cortex

J Neurophysiol. 2013 Apr;109(8):2192-204. doi: 10.1152/jn.00368.2012. Epub 2013 Jan 23.

Abstract

Somatic sensory signals provide a major source of feedback to motor cortex. Changes in somatosensory systems after stroke or injury could profoundly influence brain computer interfaces (BCI) being developed to create new output signals from motor cortex activity patterns. We had the unique opportunity to study the responses of hand/arm area neurons in primary motor cortex to passive joint manipulation in a person with a long-standing brain stem stroke but intact sensory pathways. Neurons responded to passive manipulation of the contralateral shoulder, elbow, or wrist as predicted from prior studies of intact primates. Thus fundamental properties and organization were preserved despite arm/hand paralysis and damage to cortical outputs. The same neurons were engaged by attempted arm actions. These results indicate that intact sensory pathways retain the potential to influence primary motor cortex firing rates years after cortical outputs are interrupted and may contribute to online decoding of motor intentions for BCI applications.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain Stem Infarctions / diagnosis
  • Brain Stem Infarctions / physiopathology*
  • Efferent Pathways / physiopathology
  • Evoked Potentials, Somatosensory*
  • Feedback, Sensory
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Movement
  • Neurons / physiology
  • Quadriplegia / diagnosis
  • Quadriplegia / physiopathology
  • Upper Extremity / innervation*
  • Upper Extremity / physiology