'One-pot' synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a silver(I)-catalyzed cascade approach

Molecules. 2013 Jan 11;18(1):814-31. doi: 10.3390/molecules18010814.

Abstract

An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO(3) catalyzed 'one-pot' cascade process involving formation of two new C-N bonds and one new C-O bond.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Crystallography, X-Ray
  • Isoquinolines / chemical synthesis*
  • Isoquinolines / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Oxazines / chemical synthesis*
  • Oxazines / chemistry
  • Silver Nitrate / chemistry*

Substances

  • Isoquinolines
  • Oxazines
  • Silver Nitrate