Abstract
Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins--including histones--must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chromatin / genetics*
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Chromatin / ultrastructure
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Chromosomal Proteins, Non-Histone / genetics*
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DNA Replication / genetics*
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DNA-Binding Proteins / genetics
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Drosophila melanogaster / genetics
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Epigenesis, Genetic*
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Euchromatin / genetics
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Histone Methyltransferases
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Histone-Lysine N-Methyltransferase / genetics
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Histones / genetics
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Histones / metabolism
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Nucleosomes / genetics
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Euchromatin
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Histones
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Nucleosomes
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Transcription Factors
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Histone Methyltransferases
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Histone-Lysine N-Methyltransferase