Sympatric speciation: when is it possible in bacteria?

PLoS One. 2013;8(1):e53539. doi: 10.1371/journal.pone.0053539. Epub 2013 Jan 17.

Abstract

According to theory, sympatric speciation in sexual eukaryotes is favored when relatively few loci in the genome are sufficient for reproductive isolation and adaptation to different niches. Here we show a similar result for clonally reproducing bacteria, but which comes about for different reasons. In simulated microbial populations, there is an evolutionary tradeoff between early and late stages of niche adaptation, which is resolved when relatively few loci are required for adaptation. At early stages, recombination accelerates adaptation to new niches (ecological speciation) by combining multiple adaptive alleles into a single genome. Later on, without assortative mating or other barriers to gene flow, recombination generates unfit intermediate genotypes and homogenizes incipient species. The solution to this tradeoff may be simply to reduce the number of loci required for speciation, or to reduce recombination between species over time. Both solutions appear to be relevant in natural microbial populations, allowing them to diverge into ecological species under similar constraints as sexual eukaryotes, despite differences in their life histories.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptation, Physiological / genetics
  • Bacteria / genetics*
  • Gene Flow
  • Genetic Loci / genetics
  • Genetic Speciation*
  • Models, Genetic*
  • Recombination, Genetic
  • Sympatry / genetics*

Grant support

Funding for this work was provided by the National Science Foundation (NSF Grant DEB-0918333). Computational resources were provided by NSF Grant 0821391. B.J.S. was supported by an NSERC Canada Graduate Scholarship and a Harvard MIDAS Center for Communicable Disease Dynamics postdoctoral fellowship; J.F. by a Merck-MIT fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.