Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis

Cancer Lett. 2013 Jun 1;333(1):113-23. doi: 10.1016/j.canlet.2013.01.030. Epub 2013 Jan 22.


Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. Our results indicate that stem-like cell- and EMT-associated properties and markers should be seriously considered as new cancer-associated indicators for detecting breast cell carcinogenesis and as endpoints for intervention of carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzo(a)pyrene / toxicity
  • Breast Neoplasms / prevention & control*
  • Catechin / pharmacology
  • Cell Transformation, Neoplastic*
  • Epithelial-Mesenchymal Transition / drug effects*
  • Female
  • Grape Seed Extract / pharmacology
  • Humans
  • Nitrosamines / toxicity
  • Proanthocyanidins / pharmacology
  • Stem Cells / drug effects*
  • Stem Cells / physiology
  • Tea


  • Grape Seed Extract
  • Grape Seed Proanthocyanidins
  • Nitrosamines
  • Proanthocyanidins
  • Tea
  • Benzo(a)pyrene
  • 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • Catechin