DISC1-related signaling pathways in adult neurogenesis of the hippocampus

Gene. 2013 Apr 15;518(2):223-30. doi: 10.1016/j.gene.2013.01.015. Epub 2013 Jan 24.


Disrupted-in-schizophrenia 1 (DISC1) is a multifunctional scaffold protein which plays an important role in neurogenesis and neural development in the adult brain, especially in the dentate gyrus (DG) of the hippocampus. Accumulated research has unveiled the role of DISC1 in several aspects of neural development and neurogenesis, such as neuronal maturation, proliferation, migration, positioning, differentiation, dendritic growth, axonal outgrowth, and synaptic plasticity. Studies on the function of this protein have explored multiple facets, including variants and missense mutants in genetics, proteins interactivity and signaling pathways in molecular biology, and pathogenesis and treatment targets of major mental illness, and more. In this review, we present several signaling pathways discussed in recent research, such as the AKT signaling pathway, GABA signaling pathway, GSK3β signaling pathway, Wnt signaling pathway, and NMDA-R signaling pathway. DISC1 interacts, directly or indirectly, with these signaling pathways and they co-regulate the process of adult neurogenesis in the hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Dentate Gyrus / cytology
  • Dentate Gyrus / physiology
  • Gene Expression Regulation, Developmental
  • Glycogen Synthase Kinase 3 / metabolism
  • Glycogen Synthase Kinase 3 beta
  • Hippocampus / cytology*
  • Hippocampus / physiology*
  • Humans
  • Nerve Tissue Proteins / metabolism*
  • Neurogenesis / physiology*
  • Proto-Oncogene Proteins c-akt / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Signal Transduction*
  • Wnt Proteins / metabolism
  • gamma-Aminobutyric Acid / metabolism


  • DISC1 protein, human
  • Nerve Tissue Proteins
  • Receptors, N-Methyl-D-Aspartate
  • Wnt Proteins
  • gamma-Aminobutyric Acid
  • GSK3B protein, human
  • Glycogen Synthase Kinase 3 beta
  • Proto-Oncogene Proteins c-akt
  • Glycogen Synthase Kinase 3