Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici

Shuchun Liu; Liangdong Guo; Yongsheng Che; Ling Liu

doi:10.1016/j.fitote.2013.01.010

Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici

Fitoterapia. 2013 Mar:85:114-8. doi: 10.1016/j.fitote.2013.01.010. Epub 2013 Jan 23.

Authors

Shuchun Liu¹, Liangdong Guo, Yongsheng Che, Ling Liu

Affiliation

¹ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.

PMID: 23353656
DOI: 10.1016/j.fitote.2013.01.010

Abstract

Two new isoprenylated chromone derivatives, pestaloficiols Q (1) and R (2), and one new benzofuran derivative, pestaloficiol S (3), along with three known metabolites, anofinic acid (4), siccayne (5), and pyrenophorol (6) were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute of the C-6 secondary alcohol in 1 was deduced on the basis of circular dichroism (CD) data. Compound 5 showed cytotoxic activity against the human cancer cell lines, HeLa and HT29, with IC50 values of 48.2 and 33.9μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Ascomycota / chemistry*
Benzofurans / chemistry
Benzofurans / isolation & purification*
Chromones / chemistry
Chromones / isolation & purification*
Drug Screening Assays, Antitumor
Endophytes / chemistry*
HT29 Cells
HeLa Cells
Humans
Molecular Structure

Substances

Antineoplastic Agents
Benzofurans
Chromones