Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats

K Rathinam; S P Srivastava; P K Seth

doi:10.1002/jat.2550100107

Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats

J Appl Toxicol. 1990 Feb;10(1):39-41. doi: 10.1002/jat.2550100107.

Authors

K Rathinam¹, S P Srivastava, P K Seth

Affiliation

¹ Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Poojapura Trivandrum, India.

PMID: 2335710
DOI: 10.1002/jat.2550100107

Abstract

Adult male rats receiving tris(2-ethyl hexyl)trimellitate (TOTM) intraperitoneally for seven days exhibited no significant changes in the activities of hepatic aminopyrine-N-demethylase, aryl hydrocarbon hydroxylase or glutathione-S-transferase, or in the glutathione contents. However, except for the glutathione level, the di(2-ethyl hexyl)phthalate (DEHP)-treated group showed significant increases in the activities of these enzymes. Changes in the body weight and the absolute and relative liver weights were also observed among the DHEP-treated group.

MeSH terms

Aminopyrine N-Demethylase / metabolism
Animals
Aryl Hydrocarbon Hydroxylases / metabolism
Benzoates / administration & dosage
Benzoates / toxicity*
Body Weight / drug effects
Diethylhexyl Phthalate / administration & dosage
Diethylhexyl Phthalate / toxicity*
Glutathione Transferase / metabolism
Injections, Intraperitoneal
Liver / anatomy & histology
Liver / drug effects*
Liver / enzymology
Organ Size / drug effects
Phthalic Acids / toxicity*
Plasticizers / administration & dosage
Plasticizers / toxicity*
Rats

Substances

Benzoates
Phthalic Acids
Plasticizers
tri-(2-ethylhexyl)trimellitate
Diethylhexyl Phthalate
Aryl Hydrocarbon Hydroxylases
Aminopyrine N-Demethylase
Glutathione Transferase