Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 19 (3), 380-4

DNA Evidence for Strong Genetic Stability and Increasing Heritability of Intelligence From Age 7 to 12


DNA Evidence for Strong Genetic Stability and Increasing Heritability of Intelligence From Age 7 to 12

M Trzaskowski et al. Mol Psychiatry.


Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed by general cognitive ability (g, aka intelligence): (1) The same genes affect g throughout development, even though (2) heritability increases. It is now possible to test these hypotheses using DNA alone. From 1.7 million DNA markers and g scores at ages 7 and 12 on 2875 children, the DNA genetic correlation from age 7 to 12 was 0.73, highly similar to the genetic correlation of 0.75 estimated from 6702 pairs of twins from the same sample. DNA-estimated heritabilities increased from 0.26 at age 7 to 0.45 at age 12; twin-estimated heritabilities also increased from 0.35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence.

Similar articles

See all similar articles

Cited by 39 PubMed Central articles

See all "Cited by" articles


    1. Blakemore SJ. Imaging brain development: the adolescent brain. Neuroimage. 2012;61:397–406. - PubMed
    1. Power JD, Fair DA, Schlaggar BL, Petersen SE. The development of human functional brain networks. Neuron. 2010;67:735–748. - PMC - PubMed
    1. Giedd JN, Rapoport JL. Structural MRI of pediatric brain development: what have we learned and where are we going. Neuron. 2010;67:728–734. - PMC - PubMed
    1. Plomin R, Kosslyn S. Genes brain and cognition. Nat Neurosci. 2001;4:1153–1155. - PubMed
    1. Spearman C. General intelligence', objectively determined and measured. Am J Psychol. 1904;15:201–292.

Publication types