Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

Nat Genet. 2013 Feb;45(2):119-20. doi: 10.1038/ng.2537.


Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.

Publication types

  • News

MeSH terms

  • Hep G2 Cells
  • Hepatitis C / immunology
  • Hepatitis C / prevention & control*
  • Humans
  • Interleukins / genetics*
  • Interleukins / immunology
  • Linkage Disequilibrium
  • Models, Biological
  • Phosphorylation
  • Polymorphism, Genetic / genetics*
  • STAT1 Transcription Factor / metabolism
  • STAT2 Transcription Factor / metabolism
  • Species Specificity


  • Interleukins
  • STAT1 Transcription Factor
  • STAT2 Transcription Factor