Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease

Int J Mol Sci. 2013 Jan 28;14(2):2617-36. doi: 10.3390/ijms14022617.


Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.