[Herpes Zoster After Varicella-Zoster Vaccination]

Hautarzt. 2013 Feb;64(2):107-9. doi: 10.1007/s00105-012-2477-x.
[Article in German]


A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy. This case demonstrates that a negative VZV direct immunofluorescence assay does not exclude an infection with the vaccine strain.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antibodies, Viral / blood
  • Chickenpox Vaccine / administration & dosage
  • Chickenpox Vaccine / adverse effects*
  • Chickenpox Vaccine / immunology
  • Child, Preschool
  • Female
  • Genotype
  • Herpes Zoster / etiology*
  • Herpes Zoster / immunology
  • Herpesvirus 3, Human / genetics
  • Herpesvirus 3, Human / immunology
  • Humans


  • Antibodies, Viral
  • Chickenpox Vaccine