Activating germline R776H mutation in the epidermal growth factor receptor associated with lung cancer with squamous differentiation

J Clin Oncol. 2013 Apr 1;31(10):e161-4. doi: 10.1200/JCO.2012.42.1586. Epub 2013 Jan 28.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Base Sequence
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / therapy
  • DNA Mutational Analysis
  • Enzyme Activation / genetics
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / genetics*
  • ErbB Receptors / metabolism
  • Erlotinib Hydrochloride
  • Family Health
  • Fatal Outcome
  • Female
  • Germ-Line Mutation*
  • Humans
  • In Situ Hybridization
  • Lung / drug effects
  • Lung / pathology
  • Lung / surgery
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Middle Aged
  • Mutation, Missense
  • Neoplasms, Squamous Cell / genetics*
  • Neoplasms, Squamous Cell / pathology
  • Neoplasms, Squamous Cell / therapy
  • Pneumonectomy / methods
  • Protein Kinase Inhibitors / therapeutic use
  • Quinazolines / therapeutic use
  • Treatment Outcome

Substances

  • Protein Kinase Inhibitors
  • Quinazolines
  • Erlotinib Hydrochloride
  • ErbB Receptors