Effect of Crataeva nurvala in experimental urolithiasis

J Ethnopharmacol. 1990 Mar;28(3):313-21. doi: 10.1016/0378-8741(90)90082-5.

Abstract

The effect of oral administration of Crataeva nurvala bark decoction on calcium oxalate lithiasis has been studied in rats. The elevation of the oxalate-synthesizing liver enzyme, glycolate oxidase, produced by feeding glycollic acid was remarkably reduced with the decoction, showing a regulatory action on endogenous oxalate synthesis. Protein-bound carbohydrates were increased in the renal tissues during calculosis but these changes were not reversed with the herbal treatment. The increased deposition of stone-forming constituents in the kidneys of calculogenic rats was lowered with decoction administration. The increased urinary excretion of the crystalline constituents along with lowered magnesium excretion found in stone-forming rats was partially reversed by decoction treatment.

MeSH terms

  • Administration, Oral
  • Animals
  • Calcium Oxalate / analysis
  • Kidney / drug effects*
  • Kidney / enzymology
  • Kidney Calculi / drug therapy*
  • Male
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Inbred Strains

Substances

  • Plant Extracts
  • Calcium Oxalate