PACCRETA: clinical situations at high risk of placenta ACCRETA/percreta: impact of diagnostic methods and management on maternal morbidity

Acta Obstet Gynecol Scand. 2013 Apr;92(4):476-82. doi: 10.1111/aogs.12078. Epub 2013 Feb 15.


Background: No population-based study has assessed the prevalence of placenta accreta, the predictive value of prenatal diagnostic examinations, the maternal morbidity associated with its management, or its psychological effects. Moreover, the technical resources necessary for the safest delivery of women at risk have not been clearly identified.

Objectives: The primary objectives are to identify individual risk factors, as well as factors associated with types of management and with the healthcare facilities for postpartum hemorrhage. Secondary objectives are to (i) determine the prevalence of placenta accreta among women at risk; (ii) assess the predictive value of ultrasound and MRI for the diagnosis of placenta accreta in this population; (iii) evaluate psychological impact and physical complications; and (iv) report maternal physical complications during the year after delivery.

Design: Population-based prospective observational study of pregnant women with a placenta inserted at a uterine scar.

Setting: A total of 182 centers in eight French regions, with 270 000 deliveries annually.

Methods: We expect to include 620 women at risk of placenta accreta in two years, of whom approximately 120 (20%) will have placenta accreta.

Main outcome measures: The primary outcome measure is severe maternal hemorrhage; secondary outcome measures are maternal morbidity and deaths, predictive value of ultrasound and MRI, and psychological evaluations at 6 and 12 months.

Conclusion: This study will be the first prospective population-based study to include women at risk of placenta accreta and to investigate incidence, prenatal detection, type of management, morbidity and maternal psychological consequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cesarean Section / statistics & numerical data
  • Female
  • France / epidemiology
  • Humans
  • Placenta Accreta / diagnosis*
  • Placenta Accreta / epidemiology*
  • Placenta Accreta / therapy
  • Postpartum Hemorrhage / epidemiology*
  • Postpartum Hemorrhage / prevention & control
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Prenatal Care / statistics & numerical data
  • Prenatal Diagnosis / statistics & numerical data
  • Prevalence
  • Prospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome
  • Uterus / blood supply
  • Uterus / pathology*
  • Young Adult