Interferon-induced Transmembrane protein-3 Genetic Variant rs12252-C Is Associated With Severe Influenza in Chinese Individuals

Nat Commun. 2013;4:1418. doi: 10.1038/ncomms2433.

Abstract

The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Antibodies, Viral / blood
  • Asian Continental Ancestry Group / genetics*
  • Chemokine CCL2 / blood
  • China
  • Female
  • Gene Frequency / genetics
  • Genes, Recessive / genetics
  • Genetic Predisposition to Disease*
  • Humans
  • Influenza A Virus, H1N1 Subtype / physiology
  • Influenza, Human / blood
  • Influenza, Human / genetics*
  • Influenza, Human / immunology
  • Influenza, Human / virology*
  • Male
  • Membrane Proteins / genetics*
  • Models, Genetic
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • RNA-Binding Proteins / genetics*
  • Severity of Illness Index
  • Young Adult

Substances

  • Antibodies, Viral
  • CCL2 protein, human
  • Chemokine CCL2
  • IFITM3 protein, human
  • Membrane Proteins
  • RNA-Binding Proteins