[Painful swollen joints with weakness: what's behind all this? Case 1/2013]

Dtsch Med Wochenschr. 2013 Feb;138(6):266. doi: 10.1055/s-0032-1332841. Epub 2013 Jan 29.
[Article in German]


History and admission findings: We report on a 58-year-old patient with weight loss, weakness and polyarthralgia. She reported of recurrent drops, painful joints and muscle weakness.

Investigations: The patient had swollen joints, clubbing and cachexia. The radiogram of the hands and feet showed a hypertrophic oseoarthropathy. In further investigations we found a tumor in the upper left lung. The histology findings showed a adenocarcinoma of the lung.

Diagnosis, treatment and course: The diagnosis of a secondary hypertrophic osteoarthropathy (Pierre Marie-Bamberger syndrome) due to a adenocarcinoma of the lung was made. The patient refused a radiochemotherapy and decided to go on vacation. Further course is unknown.

Conclusions: Arthralgia is a common symptom for medical consultation. Pierre Marie-Bamberger syndrome is a rare cause of paraneoplastic arthritis. Notice that unspecific symptoms like weakness, weight loss and arthritis may result from paraneoplastic tumor disease.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Arthralgia / diagnosis
  • Arthralgia / etiology*
  • Edema / diagnosis*
  • Edema / etiology*
  • Female
  • Humans
  • Lung Neoplasms / diagnosis*
  • Middle Aged
  • Muscle Weakness / etiology
  • Osteoarthropathy, Secondary Hypertrophic / diagnosis
  • Osteoarthropathy, Secondary Hypertrophic / etiology*
  • Weight Loss