Axonal transport deficits and neurodegenerative diseases

Nat Rev Neurosci. 2013 Mar;14(3):161-76. doi: 10.1038/nrn3380. Epub 2013 Jan 30.

Abstract

The intracellular transport of organelles along an axon is crucial for the maintenance and function of a neuron. Anterograde axonal transport has a role in supplying proteins and lipids to the distal synapse and mitochondria for local energy requirements, whereas retrograde transport is involved in the clearance of misfolded and aggregated proteins from the axon and the intracellular transport of distal trophic signals to the soma. Axonal transport can be affected by alterations to various components of the transport machinery. Here, we review the current state of knowledge about axonal transport defects that might contribute to the pathogenesis of particular neurodegenerative diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axonal Transport / physiology*
  • Humans
  • Neurodegenerative Diseases / physiopathology*