Diabetic myonecrosis in a cystic fibrosis patient

Respir Care. 2013 Oct;58(10):e123-5. doi: 10.4187/respcare.02299. Epub 2013 Jan 29.


Cystic fibrosis (CF) related diabetes is an increasingly common comorbidity in CF patients, with scarce data on end-stage complications in the CF population. We report the case of a 32-year-old with poorly controlled diabetes presenting with sub-acute leg pain and focal quadriceps tenderness. Neuromuscular testing and extensive workup revealed diabetic myonecrosis. To our knowledge, this is the first reported case of diabetic myonecrosis in a patient with CF, and highlights the need for pulmonary physicians to recognize this diabetic complication in CF patients, which is associated with a poor long-term prognosis and existing microvascular complications.

Keywords: cystic fibrosis; diabetes mellitus; leg pain; microvascular; myonecrosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / diagnosis
  • Diabetes Complications / complications*
  • Diabetes Complications / diagnosis
  • Diagnosis, Differential
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Muscle, Skeletal / pathology*
  • Muscular Diseases / diagnosis
  • Muscular Diseases / etiology*
  • Necrosis
  • Thigh