Chaos game representation of gene structure

Nucleic Acids Res. 1990 Apr 25;18(8):2163-70. doi: 10.1093/nar/18.8.2163.

Abstract

This paper presents a new method for representing DNA sequences. It permits the representation and investigation of patterns in sequences, visually revealing previously unknown structures. Based on a technique from chaotic dynamics, the method produces a picture of a gene sequence which displays both local and global patterns. The pictures have a complex structure which varies depending on the sequence. The method is termed Chaos Game Representation (CGR). CGR raises a new set of questions about the structure of DNA sequences, and is a new tool for investigating gene structure.

MeSH terms

  • Animals
  • Bacteria / genetics
  • Bacteriophages / genetics
  • Base Sequence*
  • DNA / genetics*
  • Genes*
  • Humans
  • Mathematics
  • Myxomycetes / genetics
  • Plants / genetics
  • Probability
  • Proto-Oncogenes
  • Viruses / genetics

Substances

  • DNA