Hyperglycemia increases the risk of death in extremely preterm baboons

Pediatr Res. 2013 Mar;73(3):337-43. doi: 10.1038/pr.2012.184. Epub 2012 Dec 7.


Background: Transient neonatal hyperglycemia (HG) has been reported in up to 80% of extremely preterm human infants. We hypothesize that severe HG is associated with increased morbidity and mortality in preterm baboons.

Methods: Sixty-six baboons born at 67% of gestation were studied. HG was defined as serum glucose level ≥150 mg/dl during the first week of life. Animals were stratified into two groups: severe HG (≥8 events) and nonsevere HG (<8 events).

Results: HG developed in 65 of the 66 (98%) baboons that were included. A total of 3,386 glucose measurements were obtained. The mean serum glucose level was 159 ± 69 mg/dl for the severe HG group and 130 ± 48 mg/dl for the nonsevere HG group during the first week of life. No differences were found in gender, birth weight, sepsis, patent ductus arteriosus, or oxygenation/ventilation indexes between groups. Severe HG was associated with early death even after controlling for sepsis, postnatal steroid exposure, and catecholamine utilization.

Conclusion: HG is common in preterm baboons and is not associated with short-term morbidity. Severe HG occurring in the first week of life is associated with early death in preterm baboons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Birth Weight
  • Blood Glucose
  • Disease Models, Animal*
  • Female
  • Humans
  • Hyperglycemia / mortality*
  • Hyperglycemia / physiopathology*
  • Infant, Extremely Premature
  • Infant, Newborn
  • Logistic Models
  • Male
  • Papio
  • Sex Factors


  • Blood Glucose