Prediction of renal end points in chronic kidney disease

Kidney Int. 2013 Feb;83(2):189-91. doi: 10.1038/ki.2012.418.

Abstract

Estimated glomerular filtration rate and albuminuria are dominant clinical predictors of renal outcomes in chronic kidney disease. Wong and collaborators report that BMP-7 and transforming growth factor-β1 improve risk discrimination for renal end points in type 2 diabetes. However, to develop predictive models, clearly defined, clinically meaningful, validated end points must be used. End-stage renal disease and kidney transplantation remain the most definitive renal end points, whereas doubling of serum creatinine and death from renal disease lack rigor.

Publication types

  • Comment

MeSH terms

  • Bone Morphogenetic Protein 7 / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetic Nephropathies / blood*
  • Female
  • Humans
  • Kidney Failure, Chronic / blood*
  • Male
  • Transforming Growth Factor beta1 / blood*

Substances

  • Bone Morphogenetic Protein 7
  • Transforming Growth Factor beta1