The Innovative Evolution of Cancer Gene and Cellular Therapies

Cancer Gene Ther. 2013 Mar;20(3):141-9. doi: 10.1038/cgt.2012.93. Epub 2013 Feb 1.

Abstract

We provide an overview of the latest developments in cancer gene therapy--from the bench to early-stage clinical trials. We describe the most recent work of worldwide teams including experienced scientists and clinicians, reflecting the recent emergence of gene therapy from the 'Valley of Death'. The treatment efficacy of clinical gene therapy has now been shown in a number of diseases including cancer and we are observing a renewed interest by big pharmaceutical and biotechnology companies most obviously demonstrated by Amgen's acquisition of Biovex for up to USD$1 billion. There is an opportunity to be cautiously hopeful regarding the future of gene therapy in the clinic and we review here some of the most recent progress in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Cell- and Tissue-Based Therapy*
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Gene Transfer Techniques
  • Genetic Therapy*
  • Genetic Vectors
  • Humans
  • Immunotherapy
  • Molecular Targeted Therapy
  • Neoplasms / genetics*
  • Neoplasms / therapy*
  • Precision Medicine
  • RNA Interference

Substances

  • Biomarkers, Tumor