Conformational ensembles in GPCR activation

Cell. 2013 Jan 31;152(3):385-6. doi: 10.1016/j.cell.2013.01.025.


Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.

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