Chlamydia trachomatis control requires a vaccine

Vaccine. 2013 Apr 8;31(15):1892-7. doi: 10.1016/j.vaccine.2013.01.024. Epub 2013 Jan 29.


As the most common reported communicable disease in North America and Europe, Chlamydia trachomatis is the focus of concerted public health control efforts based on screening and treatment. Unexpectedly control efforts are accompanied by rising reinfection rates attributed in part to arresting the development of herd immunity. Shortening the duration of infection through the testing and treatment program is the root cause behind the arrested immunity hypothesis and because of this a vaccine will be essential to control efforts. Advances in Chlamydia vaccinomics have revealed the C. trachomatis antigens that can be used to constitute a subunit vaccine and a vaccine solution appears to be scientifically achievable. We propose that an accelerated C. trachomatis vaccine effort requires coordinated partnership among academic, public health and private sector players together with a commitment to C. trachomatis vaccine control as a global public health priority.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Vaccines* / immunology
  • Chlamydia Infections / epidemiology
  • Chlamydia Infections / immunology
  • Chlamydia Infections / prevention & control*
  • Chlamydia trachomatis* / immunology
  • Global Health
  • Health Policy* / trends
  • Humans
  • Immunity, Herd
  • Public Health / methods*
  • Public Health / trends
  • Vaccines, Subunit / immunology


  • Bacterial Vaccines
  • Vaccines, Subunit