A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies

Fitoterapia. 2013 Apr;86:35-47. doi: 10.1016/j.fitote.2013.01.018. Epub 2013 Jan 31.

Abstract

Uncaria rhynchophylla (Miq.) Jacks, Rubiaceae, is one of the original plants of the important Chinese crude drug, Gou-teng, mainly used for the treatment of convulsion, hypertension, epilepsy, eclampsia, and cerebral diseases. The pharmacological activities of this plant are related to the presence of active compounds predominantly indole alkaloids. In this article, we have reviewed some reports about the pharmacological activities of the main indole alkaloids isolated from U. rhynchophylla. This review paper will contribute to the studies on the chemistry, safety and quality control of medicinal preparations containing Uncaria species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology*
  • Antihypertensive Agents / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Humans
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Neuroprotective Agents / pharmacology*
  • Uncaria / chemistry*

Substances

  • Anticonvulsants
  • Antihypertensive Agents
  • Drugs, Chinese Herbal
  • Indole Alkaloids
  • Neuroprotective Agents
  • gou-teng