Simple and rapid biosynthesis of stable silver nanoparticles using dried leaves of Catharanthus roseus. Linn. G. Donn and its anti microbial activity

Colloids Surf B Biointerfaces. 2013 May 1;105:194-8. doi: 10.1016/j.colsurfb.2013.01.003. Epub 2013 Jan 7.


Nanoparticles have been used to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. The plant extracts are eco-friendly, economical and cost effective for synthesis of large scale of nanoparticles. In this paper we represent the synthesis of silver nanoparticles (AgNPs) from room dried leaves of Vinca rosea. The AgNPs were characterized by UV-vis spectroscopy. The AgNPs are crystalline in nature, were determined from scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX), X-ray diffraction patterns (XRD), and also the size of the NPs was calculated by using Hariba Nanoparticle analyzer and the stability was calculated by using the Zetapotential. The nanoparticles obtained from leaf extracts were of size 27±2 and 30±2 respectively and Zetapotential of AgNPs was found to be -63.1 mV, so it indicates the dispersion and stability. The synthesized AgNPs have very good antimicrobial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Catharanthus / chemistry*
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Scanning
  • Nanoparticles
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Silver / chemistry*
  • Silver / pharmacology*


  • Anti-Bacterial Agents
  • Plant Extracts
  • Silver