Maxillary sinus grafting with biphasic calcium phosphate ceramics: clinical and histologic evaluation in man

Int J Oral Maxillofac Implants. 2013 Jan-Feb;28(1):51-6. doi: 10.11607/jomi.2667.


Purpose: To evaluate the clinical and histologic aspects of bone formation in maxillary sinus augmentation using macroporous biphasic calcium phosphate (MBCP) comprising hydroxyapatite/tricalcium phosphate (HA/TCP) 60/40 as bone-grafting material.

Materials and methods: A total of 10 patients and 12 sinuses grafted with MBCP in two-stage sinus augmentation were included in the present study. After a healing period of 6 months, bone core biopsies were harvested during implant insertion and evaluated under light microscopy.

Results: The histologic examination showed that the MBCP particles were in close contact with new bone in all biopsies. Histomorphometric evaluation demonstrated that newly formed bone constituted 28.3% ± 2.7%, residual grafted material 27.3% ± 1.2%, and marrow spaces 45.9% ± 1.9%.

Conclusions: Histologic investigation showed that the MBCP grafted particles were embedded and integrated in the newly formed bone; this bone was in close and tight contact with the biomaterial particles. Data from the preliminary results demonstrated that MBCP is a biocompatible and osteoconductive material that can be successfully used as a grafting material for sinus floor augmentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bone Regeneration
  • Bone Substitutes / therapeutic use*
  • Ceramics / therapeutic use*
  • Durapatite
  • Female
  • Humans
  • Hydroxyapatites / therapeutic use*
  • Male
  • Maxillary Sinus / cytology
  • Middle Aged
  • Osseointegration / physiology*
  • Osteogenesis / physiology*
  • Sinus Floor Augmentation / methods*
  • Wound Healing


  • Bone Substitutes
  • Hydroxyapatites
  • hydroxyapatite-beta tricalcium phosphate
  • Durapatite