Inflammatory acne management with a novel prescription dietary supplement

J Drugs Dermatol. 2012 Dec;11(12):1428-33.


Background: Inflammatory acne, particularly in post-adolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration of oral tetracyclines. Long-term acne treatment with such drugs, however, is frequently accompanied by undesirable adverse reactions, including gastrointestinal disturbances, antianabolic effects, headaches, tinnitus, and photosensitivity.

Objective: To assess the usefulness of a novel dietary supplement in the overall management of patients with inflammatory acne vulgaris.

Methods: 235 patients with inflammatory acne vulgaris were enrolled by dermatologists in a multicenter, open-label, 8-week, prospective study evaluating the effects of adding NicAzel, 1 to 4 tablets daily, to their current acne treatment regimen.

Results: A statistically significant (P<.0001) number of patients demonstrated improvement over their previous acne treatment regimens after both 4 and 8 weeks of NicAzel (nicotinamide, azelaic acid, zinc, pyridoxine, copper, folic acid; Elorac Inc, Vernon Hills, IL) use. At week 8, 88% of the patients experienced a visible reduction in inflammatory lesions, and 81% of the patients rated their appearance as much or moderately better compared with baseline. Three-quarters (76%) of the patients thought NicAzel was at least as effective as previous treatment with oral antibiotics.

Conclusion: Patients with inflammatory acne showed significant improvement in acne severity and overall appearance when NicAzel was added to their existing treatment regimen.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology*
  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Copper / adverse effects
  • Copper / therapeutic use*
  • Dicarboxylic Acids / adverse effects
  • Dicarboxylic Acids / therapeutic use*
  • Dietary Supplements* / adverse effects
  • Drug Therapy, Combination
  • Female
  • Folic Acid / adverse effects
  • Folic Acid / therapeutic use*
  • Humans
  • Inflammation / drug therapy
  • Inflammation / pathology
  • Male
  • Middle Aged
  • Niacinamide / adverse effects
  • Niacinamide / therapeutic use*
  • Patient Satisfaction
  • Prescription Drugs
  • Prospective Studies
  • Pyridoxine / adverse effects
  • Pyridoxine / therapeutic use*
  • Tetracyclines / therapeutic use
  • Treatment Outcome
  • Young Adult
  • Zinc / adverse effects
  • Zinc / therapeutic use*


  • Anti-Bacterial Agents
  • Dicarboxylic Acids
  • Prescription Drugs
  • Tetracyclines
  • Niacinamide
  • Copper
  • Folic Acid
  • azelaic acid
  • Zinc
  • Pyridoxine