Nuclear scintigraphy findings for Askin tumor with In111-pentetreotide, Tc99m-MIBI and F18-FDG

J Radiol Case Rep. 2012 Oct;6(10):32-9. doi: 10.3941/jrcr.v6i10.1163. Epub 2012 Oct 1.

Abstract

Askin tumor is a rare disease which had previously been reported as being thallium-201 and gallium-67 avid. Varying data regarding 18F- fluorodeoxyglucose metabolism has been described with Ewing family of soft tissue tumors. In this case, we present a patient found to have an Askin tumor of the left chest wall which demonstrated indium-111 pentetreotide and technetium-99m MIBI avidity. The lesion did not show 18F- fluorodeoxyglucose hypermetabolism in this case despite the aggressiveness of the tumor. The patient was treated with surgical excision of the tumor and chemotherapy. Subsequently, contrast enhanced CT, indium-111 pentetreotide and technetium 99m-MIBI showed that the lesion had regressed. These findings suggest that Askin tumor can demonstrate Indium-111 pentetreotide and technetium 99m-MIBI uptake and need not be hypermetabolic on 18F-fluorodeoxyglucose exam.

Keywords: Askin; Chest wall mass; Ewing; FDG; MIBI; PNET; Pediatric radiology; Pentetreotide; Primitive neuroectodermal tumor.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / pathology
  • Female
  • Fluorodeoxyglucose F18* / metabolism
  • Humans
  • Radionuclide Imaging / methods
  • Radiopharmaceuticals* / metabolism
  • Sarcoma, Ewing / diagnostic imaging*
  • Sarcoma, Ewing / pathology
  • Somatostatin / analogs & derivatives*
  • Technetium Tc 99m Sestamibi* / metabolism
  • Thoracic Wall / diagnostic imaging*
  • Thoracic Wall / pathology

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Somatostatin
  • Technetium Tc 99m Sestamibi
  • pentetreotide

Supplementary concepts

  • Askin Tumor