[Clinical characteristics of short tear film breakup time (BUT) -type dry eye]

Nippon Ganka Gakkai Zasshi. 2012 Dec;116(12):1137-43.
[Article in Japanese]


Purpose: To evaluate the clinical characteristics and management of short tear film breakup time (BUT) -type dry eye.

Methods: Clinical background and post-treatment changes of symptoms in 77 patients with short BUT -type dry eye were investigated. Treatment consisted of artificial-tear eye-drop instillation and, if necessary, the addition of a low-density-level steroid, hyaluronic acid, a low-density-level cyclopentolate prepared by ourselves and punctal plugs inserted into the upper and lower lacrimal puncta.

Results: There were three times more women than men among the patients, and the peak age of occurrence was in the twenties in the men and in the sixties in the women. Our findings show that visual display terminal (VDT) work, contact lens (CL) wear, and changes in the sex hormones may initiate subjective symptoms. Some patients had simultaneous conjunctivochalasis, allergic conjunctivitis, and meibomian gland dysfunction. Nineteen patients (24.7%) were effectively treated with eye-drop instillation alone. Thirty-seven patients (48.1%) required punctal-plug insertion, which was completely effective in only 8 of them (21.6%).

Conclusion: Mainly young men and menopausal women contract short BUT -type dry eye. Changes in sex hormones, VDT work and CL wear may be causal, and the disease cannot be controlled by eyedrop and punctal-plug treatment alone.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Dry Eye Syndromes / diagnosis
  • Dry Eye Syndromes / drug therapy*
  • Dry Eye Syndromes / pathology
  • Eyelid Diseases / diagnosis
  • Eyelid Diseases / drug therapy
  • Eyelid Diseases / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions / therapeutic use*
  • Sex Distribution
  • Treatment Outcome
  • Young Adult


  • Ophthalmic Solutions