Autoantibodies in juvenile dermatomyositis

Clin Exp Rheumatol. Mar-Apr 1990;8(2):193-6.

Abstract

Fourteen patients with juvenile dermatomyositis (JDM) have been investigated for the presence of several serum autoantibodies: antinuclear (ANA), anti-single-stranded and double-stranded DNA, anti-histones, anti-Sm, anti-ribonucleoprotein, anti-SSA/SSB, anti-PM-1, anti-Jo-1, anti-mitochondrial, anti-smooth muscle, anti-gastric parietal cells, anti-cardiolipin (ACA) antibodies and rheumatoid factor. Patients were negative for all autoantibodies except for ANA and ACA. ANA were detected in 50% of the patients when tested on rat liver, but the percentage of positivity rose to 86% when HEp-2 cells were used as substrate. This finding suggests that HEp-2 cells represent a more sensitive substrate than rat liver for the detection of ANA in JDM. Three patients were positive for ACA; two of these presented vascular complications, thus suggesting a possible relationship between ACA and vascular involvement in JDM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Antinuclear / analysis
  • Autoantibodies / analysis*
  • Cardiolipins / immunology
  • Child
  • Child, Preschool
  • Dermatomyositis / immunology*
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Infant
  • Male
  • Reference Values

Substances

  • Antibodies, Antinuclear
  • Autoantibodies
  • Cardiolipins
  • Immunoglobulin G