Divided nevus of the eyelid: review of embryology, pathology and treatment

Am J Otolaryngol. 2013 May-Jun;34(3):223-9. doi: 10.1016/j.amjoto.2013.01.004. Epub 2013 Feb 4.


Divided nevus, which is also known as "kissing nevus," "split ocular nevus" and "panda nevus" is a rare congenital dermatological abnormality that occurs on opposing margins of upper and lower eyelids. There is a paucity of literature on this rare anomaly, with most knowledge from this disease process derived from isolated case reports and series. The purpose of this study is to report a new case of divided nevus of the eyelid and to discuss the unique embryology, pathology, and potential treatment options for this rare entity. A systematic review of literature was performed of the English literature on PubMed and Medline with just under 150 cases reported in the literature. The vast majority of the divided nevi seen in this review were medium sized and of the melanocytic intradermal type. There were no described cases of malignant transformation in any of the documented cases. Numerous methods for reconstruction were described including the entire reconstructive ladder with both one and two staged approaches. In this review, we present basic guidelines to the reconstruction of these complicated defects, although ultimate treatment should be individualized and dependent on surgeon comfort.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Eyelid Neoplasms / congenital
  • Eyelid Neoplasms / embryology
  • Eyelid Neoplasms / pathology
  • Eyelid Neoplasms / surgery*
  • Humans
  • Nevus, Pigmented / congenital
  • Nevus, Pigmented / embryology
  • Nevus, Pigmented / pathology
  • Nevus, Pigmented / surgery*
  • Plastic Surgery Procedures / methods
  • Skin Neoplasms / congenital
  • Skin Neoplasms / embryology
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery*
  • Skin Transplantation