Adverse Events After Endovascular Treatment of Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis

Mult Scler. 2013 Jun;19(7):961-3. doi: 10.1177/1352458513475491. Epub 2013 Feb 4.


Although it is debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients undergo endovascular treatment (ET) of CCSVI. A study is ongoing in Italy to evaluate the clinical outcome of ET. Severe adverse events (AEs) occurred in 15/462 subjects at a variable interval after ET: jugular thrombosis in seven patients, tetraventricular hydrocephalus, stroke, paroxysmal atrial fibrillation, status epilepticus, aspiration pneumonia, hypertension with tachicardia, or bleeding of bedsore in the remaining seven cases. One patient died because of myocardial infarction 10 weeks after ET. The risk of severe AEs related to ET for CCSVI must be carefully considered.

Keywords: CCSVI; endovascular treatment; multiple sclerosis.

MeSH terms

  • Adult
  • Brain / blood supply
  • Endovascular Procedures / adverse effects*
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / therapy*
  • Spinal Cord / blood supply
  • Venous Insufficiency / complications
  • Venous Insufficiency / therapy*