Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Chem Commun (Camb). 2013 Mar 11;49(20):2010-2. doi: 10.1039/c3cc38693g.

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Carbocyanines / chemistry
  • Cell Survival / drug effects
  • DNA / chemistry*
  • Doxorubicin / chemistry*
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry*
  • Drug Resistance, Neoplasm / drug effects
  • Female
  • Humans
  • MCF-7 Cells
  • Nanostructures / chemistry
  • Nanostructures / toxicity

Substances

  • Carbocyanines
  • Drug Carriers
  • cyanine dye 5
  • Doxorubicin
  • DNA