Does correction of metabolic acidosis slow chronic kidney disease progression?

Curr Opin Nephrol Hypertens. 2013 Mar;22(2):193-7. doi: 10.1097/MNH.0b013e32835dcbbe.


Purpose of review: Most patients with chronic kidney disease (CKD) have progressive decline in glomerular filtration rate (GFR), despite current treatment practices. Recent studies support that dietary acid reduction with oral sodium based alkali or base-inducing food types add kidney protection to that provided by current kidney-protective interventions. Related studies also support that correction of metabolic acidosis with dietary acid reduction slows CKD progression. We reviewed these recent studies that show improvement in CKD parameters and slower CKD progression in response to improvement of CKD-associated metabolic acidosis with these interventions.

Recent findings: Animal as well as human models of CKD show that alkali treatment ameliorates indices of kidney injury and also might slow GFR decline in patients with or without metabolic acidosis. These benefits have been similar with oral sodium-based alkali and base-inducing fruits and vegetables, supporting dietary acid reduction as an effective adjunct to conventional kidney-protective interventions.

Summary: Recent studies suggest that metabolic acidosis mediates nephropathy progression, and its treatment with the comparatively inexpensive and well tolerated intervention of dietary acid reduction holds promise to be an additional kidney-protective strategy in CKD management.

Publication types

  • Review

MeSH terms

  • Acid-Base Equilibrium / drug effects*
  • Acidosis / diagnosis
  • Acidosis / metabolism
  • Acidosis / physiopathology
  • Acidosis / therapy*
  • Animals
  • Diet* / adverse effects
  • Disease Progression
  • Fruit*
  • Glomerular Filtration Rate / drug effects
  • Humans
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / physiopathology
  • Renal Insufficiency, Chronic / diagnosis
  • Renal Insufficiency, Chronic / metabolism
  • Renal Insufficiency, Chronic / physiopathology
  • Renal Insufficiency, Chronic / therapy*
  • Sodium Bicarbonate / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Vegetables*


  • Sodium Bicarbonate