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Review
. 2013 Mar;14(3):179-90.
doi: 10.1038/nrg3395. Epub 2013 Feb 5.

Q(ST)-F(ST) comparisons: evolutionary and ecological insights from genomic heterogeneity

Tuomas Leinonen  1 , R J Scott McCairns, Robert B O'Hara, Juha Merilä
Affiliations
Review

Q(ST)-F(ST) comparisons: evolutionary and ecological insights from genomic heterogeneity

Tuomas Leinonen et al. Nat Rev Genet. 2013 Mar.

Abstract

Comparative studies of the divergence of quantitative traits and neutral molecular markers, known as Q(ST)-F(ST) comparisons, provide a means for researchers to distinguish between natural selection and genetic drift as causes of population differentiation in complex polygenic traits. The use of Q(ST)-F(ST) comparisons has increased rapidly in the last few years, highlighting the utility of this approach for addressing a wide range of questions that are relevant to evolutionary and ecological genetics. These studies have also provided lessons for the design of future Q(ST)-F(ST) comparisons. Methods based on the Q(ST)-F(ST) approach could also be used to analyse various types of 'omics' data in new and revealing ways.

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