hESC-derived pancreatic progenitors

Cell Res. 2013 May;23(5):592-4. doi: 10.1038/cr.2013.20. Epub 2013 Feb 5.


Successful derivation of pancreatic progenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs), instead of derived β cells, as an alternative transplantable source in β cell replacement therapy. Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation.

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • CD24 Antigen / metabolism
  • Cell Differentiation
  • Embryonic Stem Cells / cytology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Insulin-Secreting Cells / cytology
  • Mice
  • Nerve Tissue Proteins / metabolism
  • Pancreas / cytology*
  • Thromboplastin / metabolism


  • Basic Helix-Loop-Helix Transcription Factors
  • CD24 Antigen
  • NEUROG3 protein, human
  • Nerve Tissue Proteins
  • Thromboplastin