Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans

Eur J Clin Pharmacol. 1990;38(2):165-9. doi: 10.1007/BF00265978.

Abstract

In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and metabolic clearances were decreased by 30% and 27% while after ranitidine the clearances were decreased by 10% and 7% respectively. Since smokers regulate their smoke intake based in large part on their nicotine blood levels these results suggest that the diminished nicotine total clearance in the presence of cimetidine could be important in assisting smoking reduction or cessation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cimetidine / pharmacology*
  • Cotinine / pharmacokinetics
  • Double-Blind Method
  • Humans
  • Injections, Intravenous
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Middle Aged
  • Nicotine / blood
  • Nicotine / pharmacokinetics*
  • Nicotine / urine
  • Random Allocation
  • Ranitidine / pharmacology*

Substances

  • Nicotine
  • Cimetidine
  • Ranitidine
  • Cotinine