A 64-year-old man underwent resection of a mesenteric desmoid tumor in May 2006. He presented with a chief complaint of loss of appetite at a local hospital in July 2011. A huge abdominal tumor was detected on computed tomography, and he was referred to our hospital. We suspected recurrence of the desmoid tumor 5 years and 2 months after the first surgery and performed re-resection, revealing two tumors, measuring 32×29×10cm and 7.0×6.0×4.5cm, respectively. Histopathologic examination yielded a diagnosis of mesenteric desmoid tumor recurrence. Four months after re-resection, the patient is alive without recurrence.