In vivo frequency domain optoacoustic tomography

Opt Lett. 2012 Aug 15;37(16):3423-5. doi: 10.1364/OL.37.003423.


Optoacoustic imaging has been primarily implemented in the time domain, i.e., using ultrashort nanosecond laser pulses for illumination. Alternatively, frequency domain optoacoustic imaging can be performed when employing amplitude modulated light sources. We present herein a tomographic implementation of optoacoustic imaging using a linear frequency modulated laser source. The method developed demonstrated the ability to produce tomographic images of optical absorbing phantoms and in vivo images, by enabling visualization of the mouse tail following ICG injection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Equipment Design
  • Equipment Failure Analysis
  • Image Enhancement / instrumentation*
  • Lasers*
  • Mice
  • Photoacoustic Techniques / instrumentation*
  • Tail / diagnostic imaging*
  • Tomography / instrumentation*
  • Ultrasonography