Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source

Opt Lett. 2013 Feb 1;38(3):338-40. doi: 10.1364/OL.38.000338.


Despite the challenges in achieving high phase stability, Doppler swept-source/Fourier-domain optical coherence tomography (OCT) has advantages of less fringe washout and faster imaging speeds compared to spectral/Fourier-domain detection. This Letter demonstrates swept-source OCT with a vertical cavity surface-emitting laser light source at 400 kHz sweep rate for phase-sensitive Doppler imaging, measuring pulsatile total retinal blood flow with high sensitivity and phase stability. A robust, simple, and computationally efficient phase stabilization approach for phase-sensitive swept-source imaging is also presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Equipment Design
  • Fourier Analysis
  • Humans
  • Lasers
  • Light
  • Regional Blood Flow
  • Retina / pathology*
  • Retinal Vessels / pathology
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / instrumentation
  • Tomography, Optical Coherence / methods*