Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Nat Struct Mol Biol. 2013 Feb;20(2):135-8. doi: 10.1038/nsmb.2508.


With the recent successes in determining membrane protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, thus providing structure/function information not otherwise available.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Base Sequence
  • Cluster Analysis
  • Genomics / methods*
  • Humans
  • Membrane Proteins / genetics*
  • Models, Genetic
  • Molecular Sequence Data
  • Protein Structure, Secondary*
  • Proteome / genetics*
  • Sequence Analysis, DNA
  • Sequence Homology


  • Membrane Proteins
  • Proteome