Abstract
Sporadic colorectal cancer (sCRC) is one of the most frequent types of cancer in Europe. Despite understanding of its tumorigenesis, the metastatic process is not yet clear. In this article, we review the most significant genetic and proteomic advances that have been made in regards to research of the sCRC metastatic process, and the new biomarkers that are able to predict disease prognosis or response to treatments, in order to define personalized medicine.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism*
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Carcinoma / genetics
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Carcinoma / metabolism*
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Carcinoma / secondary
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Chromosome Aberrations
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / metabolism*
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Colorectal Neoplasms / pathology
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Humans
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Liver Neoplasms / genetics
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Liver Neoplasms / metabolism*
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Liver Neoplasms / secondary
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Oligonucleotide Array Sequence Analysis
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Peptide Mapping
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Prognosis
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Protein Array Analysis
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Proteome / genetics
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Proteome / metabolism*
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Proteomics
Substances
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Biomarkers, Tumor
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Proteome