MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation

World J Gastroenterol. 2013 Jan 28;19(4):440-4. doi: 10.3748/wjg.v19.i4.440.


A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer.

Keywords: Hepatocellular oncogenesis; Hepatocyte nuclear factor-4α; Interleukin-6; MicroRNA; Signal transducer and activator of transcription 3.

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Carcinogenesis / metabolism*
  • Carcinogenesis / pathology
  • Feedback, Physiological
  • Gene Expression Regulation, Neoplastic
  • Hepatitis / genetics
  • Hepatitis / metabolism*
  • Hepatitis / pathology
  • Hepatocyte Nuclear Factor 4 / metabolism
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology
  • MicroRNAs / metabolism*
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction


  • Hepatocyte Nuclear Factor 4
  • MicroRNAs
  • STAT3 Transcription Factor