Morphological and hemodynamic analysis of mirror posterior communicating artery aneurysms

PLoS One. 2013;8(1):e55413. doi: 10.1371/journal.pone.0055413. Epub 2013 Jan 31.

Abstract

Background and purpose: Hemodynamic factors are commonly believed to play an important role in the pathogenesis, progression, and rupture of cerebral aneurysms. In this study, we aimed to identify significant hemodynamic and morphological parameters that discriminate intracranial aneurysm rupture status using 3-dimensional-angiography and computational fluid dynamics technology.

Materials and methods: 3D-DSA was performed in 8 patients with mirror posterior communicating artery aneurysms (Pcom-MANs). Each pair was divided into ruptured and unruptured groups. Five morphological and three hemodynamic parameters were evaluated for significance with respect to rupture.

Results: The normalized mean wall shear stress (WSS) of the aneurysm sac in the ruptured group was significantly lower than that in the unruptured group (0.52±0.20 versus 0.81±0.21, P = .012). The percentage of the low WSS area in the ruptured group was higher than that in the unruptured group (4.11±4.66% versus 0.02±0.06%, P = .018). The AR was 1.04±0.21 in the ruptured group, which was significantly higher than 0.70±0.17 in the unruptured group (P = .012). By contrast, parameters that had no significant differences between the two groups were OSI (P = .674), aneurysm size (P = .327), size ratio (P = .779), vessel angle (P = 1.000) and aneurysm inclination angle (P = 1.000).

Conclusions: Pcom-MANs may be a useful disease model to investigate possible causes of aneurysm rupture. The ruptured aneurysms manifested lower WSS, higher percentage of low WSS area, and higher AR, compared with the unruptured one. And hemodynamics is as important as morphology in discriminating aneurysm rupture status.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiography / methods*
  • Biomechanical Phenomena
  • China
  • Hemodynamics / physiology*
  • Humans
  • Imaging, Three-Dimensional / methods
  • Intracranial Aneurysm / pathology*
  • Intracranial Aneurysm / physiopathology*
  • Models, Cardiovascular
  • Pulsatile Flow / physiology
  • Shear Strength

Grant support

This research was supported by the National Natural Science Foundation of China (Grant No. 81171092 and 81171093), Rising-star Plan and Key Project of Shanghai Science and Technology Committee (Grant No. 11QA1408400 and 11JC1415800). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.