Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management

Br J Haematol. 2013 Apr;161(1):3-14. doi: 10.1111/bjh.12235. Epub 2013 Feb 6.


Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.

Publication types

  • Review

MeSH terms

  • Antigens, Human Platelet / immunology
  • Biomarkers / blood
  • Female
  • Humans
  • Infant, Newborn
  • Perinatal Care / methods
  • Platelet Transfusion / methods
  • Pregnancy
  • Prenatal Care / methods
  • Thrombocytopenia, Neonatal Alloimmune / diagnosis*
  • Thrombocytopenia, Neonatal Alloimmune / immunology
  • Thrombocytopenia, Neonatal Alloimmune / therapy


  • Antigens, Human Platelet
  • Biomarkers