Charity begins at home: non-coding RNA functions in DNA repair

Nat Rev Mol Cell Biol. 2013 Mar;14(3):181-9. doi: 10.1038/nrm3523. Epub 2013 Feb 6.


During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced at DNA breaks and mediate the repair process. These intriguing observations raise the possibility that crosstalk between ncRNAs and the DDR might provide a means of efficient and accurate DNA repair and facilitate the maintenance of genomic stability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle / genetics
  • Cell Physiological Phenomena
  • DNA Breaks*
  • DNA Repair*
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • RNA, Untranslated / genetics*
  • RNA, Untranslated / metabolism*
  • Signal Transduction


  • MicroRNAs
  • RNA, Untranslated