Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer

Am J Surg. 2013 Jun;205(6):631-5. doi: 10.1016/j.amjsurg.2012.05.035. Epub 2013 Feb 4.

Abstract

Background: We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC).

Methods: Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5' URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (http://bioinfo.iconcologia.net/SNPstats), Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea).

Results: The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%).

Conclusions: Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC.

MeSH terms

  • CD18 Antigens / genetics*
  • Carcinoma, Papillary / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Integrin beta1 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Republic of Korea
  • Thyroid Neoplasms / genetics*

Substances

  • CD18 Antigens
  • Integrin beta1