Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer

Am J Surg. 2013 Jun;205(6):631-5. doi: 10.1016/j.amjsurg.2012.05.035. Epub 2013 Feb 4.


Background: We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC).

Methods: Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5' URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (, Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea).

Results: The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%).

Conclusions: Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC.

MeSH terms

  • CD18 Antigens / genetics*
  • Carcinoma, Papillary / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Integrin beta1 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Republic of Korea
  • Thyroid Neoplasms / genetics*


  • CD18 Antigens
  • Integrin beta1